endogenous virus
- Guideline or reference source
- ICHQ5A Viral safety evaluation of biotech products
- Definition
- Viral entity whose genome is part of the germ line of the species of origin of the cell line and is covalently integrated into the genome of animal from which the parental cell line was derived. For the purposes of this document, intentionally introduced, non-integrated viruses such as EBV used to immortalise cell substrates or Bovine Papilloma Virus fit in this category.
- Broader Term
- virus
- Related Term
- adventitious virus
- non-endogenous virus
- non-specific model virus
- relevant virus
- specific model virus
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