reference item
- Guideline or reference source
- ENV/JM/MONO(2004)26 OECD THE APPLICATION OF THE PRINCIPLES OF GLP TO IN VITRO STUDIES
- Definition
- Test guidelines for in vitro studies mandate in many cases the use of appropriate positive, negative and/or vehicle control items which may not serve, however, as the GLP definition of “reference items” implies, to grade the response of the test system to the test item, but rather to control the proper performance of the test system. Since the purpose of these positive, negative and/or vehicle control items may be considered as analogous to the purpose of a reference item, the definition of the latter may be regarded as covering the terms “positive, negative, and/or vehicle control items” as well. The extent to which they should be analytically characterized may, however, be different from the requirements of reference items.
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