lowest-observed effect level
- Guideline or reference source
- ICHQ3C Impurities: guideline for residual solvents
- Definition
- The lowest dose of substance in a study or group of studies that produces biologically significant increases in frequency or severity of any effects in the exposed humans or animals.
- Abbreviation for
- LOEL
- Related Term
- lowest-oberved-adverse-effect level
- therapeutic dose range
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