lowest-oberved-adverse-effect level
- Guideline or reference source
- ICHQ3D Guideline for elemental impurities
- Definition
- Lowest concentration or amount of a substance (dose), found by experiment or observation, which causes an adverse effect on morphology, functional capacity, growth, development, or life span of a target organism distinguishable from normal (control) organisms of the same species and strain under defined conditions of exposure.
- Abbreviation for
- LOAEL
- Related Term
- adverse effect
- lowest-observed effect level
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