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Qdossier Qsauri
"B"

bound residue
Guideline or reference source
EMEA/CVMP/SWP/95682/2007 reflection paper on assessment paper on assessment of bioavailability of bound residues in food commodities of animal origin
Definition
Residues derived from the covalent binding of the parent drug or a metabolite of the drug and a cellular biological soluble or insoluble macromolecule. These residues are not extractable from the macromolecule by exhaustive extraction, denaturation or solubilization techniques. They do not result from the incorporation of metabolized, radiolabelled fragments of the drug into endogenous compounds, or the same macromolecule by normal biosynthetic pathways.
Related Term
bioavailable residues
extractable residue
 

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